Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 881)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0209829	0.1128390	0.8542653
Weighted median	23	0.0588987	0.0569476	0.3010142
Inverse variance weighted	23	0.0121536	0.0430973	0.7779408
Simple mode	23	0.1188111	0.0964866	0.2311844
Weighted mode	23	0.0597424	0.0660900	0.3758118

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.83484	21	0.1763872
Inverse variance weighted	26.84407	22	0.2172088

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0005422	0.0063782	0.9330595

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008164	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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