Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 880)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0346903	0.1005773	0.7335914
Weighted median	23	0.0348675	0.0579693	0.5475190
Inverse variance weighted	23	0.0297678	0.0390154	0.4454778
Simple mode	23	-0.0665295	0.1042105	0.5297941
Weighted mode	23	0.0157606	0.0680184	0.8189043

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.31971	21	0.4395738
Inverse variance weighted	21.81188	22	0.4711641

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0039584	0.0056851	0.493896

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006786	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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