Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 88)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1046687	0.0998199	0.3062926
Weighted median	23	0.0335290	0.0553759	0.5448605
Inverse variance weighted	23	0.0013961	0.0390156	0.9714558
Simple mode	23	0.0550865	0.0945942	0.5662549
Weighted mode	23	0.0699303	0.0635200	0.2828328

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.61918	21	0.7339161
Inverse variance weighted	17.88257	22	0.7129277

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.006342	0.0056423	0.2736966

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005419	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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