Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 879)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0486514	0.0998201	0.6310311
Weighted median	23	-0.0115817	0.0559587	0.8360341
Inverse variance weighted	23	0.0161663	0.0390156	0.6786149
Simple mode	23	-0.1002722	0.0903377	0.2789974
Weighted mode	23	-0.0371722	0.0661942	0.5800898

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.53252	21	0.5510197
Inverse variance weighted	20.03020	22	0.5811506

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0039804	0.0056423	0.4882743

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006122	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis