Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 878)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0953295	0.0998204	0.3504376
Weighted median	23	0.0351585	0.0564002	0.5330380
Inverse variance weighted	23	0.0100175	0.0390155	0.7973674
Simple mode	23	0.0858513	0.1002127	0.4008516
Weighted mode	23	0.0422910	0.0811236	0.6073556

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.49797	21	0.9521908
Inverse variance weighted	12.81260	22	0.9382560

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0064694	0.0056424	0.2644549

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003902	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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