Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 877)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1104050	0.0998207	0.2812221
Weighted median	23	-0.0019022	0.0544830	0.9721482
Inverse variance weighted	23	-0.0010223	0.0390157	0.9790953
Simple mode	23	-0.0196252	0.0884017	0.8263616
Weighted mode	23	0.0034071	0.0612229	0.9561226

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.96557	21	0.9098251
Inverse variance weighted	14.43633	22	0.8852726

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0068427	0.0056423	0.2386929

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004375	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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