Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 876)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0872402	0.1020864	0.4024324
Weighted median	23	0.0039502	0.0562801	0.9440438
Inverse variance weighted	23	-0.0293623	0.0403879	0.4672216
Simple mode	23	-0.0347695	0.0883185	0.6976043
Weighted mode	23	0.0029822	0.0605168	0.9611414

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.96428	21	0.4015708
Inverse variance weighted	23.57484	22	0.3699033

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0071605	0.0057704	0.2283245

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007315	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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