Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 875)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0510583	0.0998210	0.6143383
Weighted median	23	-0.0357237	0.0529395	0.4998011
Inverse variance weighted	23	-0.0371464	0.0390157	0.3410526
Simple mode	23	-0.0420747	0.0861714	0.6301913
Weighted mode	23	-0.0338407	0.0629509	0.5962679

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.65832	21	0.4799730
Inverse variance weighted	21.57991	22	0.4851888

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0054166	0.0056424	0.3479812

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006814	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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