Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 874)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0574431	0.1152955	0.6235034
Weighted median	23	-0.0771971	0.0597189	0.1961240
Inverse variance weighted	23	-0.0468169	0.0450283	0.2984696
Simple mode	23	-0.0612489	0.1020477	0.5545064
Weighted mode	23	-0.0833198	0.0712869	0.2549956

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.01608	21	0.1396959
Inverse variance weighted	29.30373	22	0.1363919

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0064026	0.0065171	0.3370693

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009316	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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