Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 873)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2294706	0.1128286	0.0547995
Weighted median	23	-0.0751041	0.0592329	0.2048177
Inverse variance weighted	23	-0.0599072	0.0457388	0.1902747
Simple mode	23	-0.0068190	0.1092240	0.9507829
Weighted mode	23	-0.0680901	0.0769851	0.3860133

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.83059	21	0.1765313
Inverse variance weighted	30.23651	22	0.1128283

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.010413	0.0063777	0.117433

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009876	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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