Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 872)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0053732	0.0998206	0.9575805
Weighted median	23	0.0016784	0.0584271	0.9770832
Inverse variance weighted	23	0.0162602	0.0390158	0.6768551
Simple mode	23	-0.0307560	0.1111263	0.7845433
Weighted mode	23	-0.0211951	0.0836580	0.8023475

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.30027	21	0.6927513
Inverse variance weighted	17.31431	22	0.7457810

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0006686	0.0056423	0.9068048

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00053	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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