Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 871)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1152230	0.1071462	0.2944046
Weighted median	23	0.0246780	0.0592047	0.6768060
Inverse variance weighted	23	0.0079923	0.0424096	0.8505193
Simple mode	23	0.0798912	0.0970073	0.4190290
Weighted mode	23	0.0395764	0.0683380	0.5683864

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.19588	21	0.2836649
Inverse variance weighted	25.99432	22	0.2519258

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0075666	0.0060564	0.2252798

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007889	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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