Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 870)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1074290	0.0998200	0.2940348
Weighted median	23	-0.0693051	0.0541499	0.2005889
Inverse variance weighted	23	-0.0714271	0.0390154	0.0671393
Simple mode	23	0.0410929	0.0972666	0.6767775
Weighted mode	23	-0.0797826	0.0645464	0.2294749

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.60372	21	0.4833617
Inverse variance weighted	20.75725	22	0.5357805

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0022109	0.0056423	0.6991253

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007306	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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