Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 87)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0728474	0.0998190	0.4735786
Weighted median	23	0.0387985	0.0597038	0.5157886
Inverse variance weighted	23	-0.0351574	0.0390152	0.3675233
Simple mode	23	0.0681343	0.1265478	0.5957015
Weighted mode	23	0.0789095	0.0805619	0.3379874

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.28438	21	0.5033177
Inverse variance weighted	21.66622	22	0.4799556

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0066326	0.0056423	0.2529435

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006811	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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