Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 869)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0462225	0.0998211	0.6480888
Weighted median	23	-0.0534234	0.0557758	0.3381511
Inverse variance weighted	23	-0.0341500	0.0390158	0.3814175
Simple mode	23	-0.0412005	0.0855220	0.6347393
Weighted mode	23	-0.0533777	0.0668769	0.4333160

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.41654	21	0.7458100
Inverse variance weighted	17.18172	22	0.7532529

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0049357	0.0056424	0.3916043

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005439	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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