Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 868)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0976735	0.0998205	0.3389701
Weighted median	23	-0.0099648	0.0590823	0.8660649
Inverse variance weighted	23	0.0039624	0.0390156	0.9191057
Simple mode	23	0.0252858	0.1014766	0.8055342
Weighted mode	23	-0.0210075	0.0731418	0.7766346

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.66128	21	0.7314233
Inverse variance weighted	17.70153	22	0.7235305

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0057548	0.0056423	0.3193689

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005367	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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