Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 867)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1126323	0.1196553	0.3572511
Weighted median	23	0.0066429	0.0628458	0.9158196
Inverse variance weighted	23	-0.0220356	0.0464234	0.6350255
Simple mode	23	0.0755540	0.1161724	0.5221938
Weighted mode	23	0.0102026	0.0895101	0.9102855

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.17578	21	0.0885122
Inverse variance weighted	31.14808	22	0.0931250

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0055636	0.0067636	0.4199877

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009535	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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