Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 866)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1182284	0.1147539	0.3146007
Weighted median	23	-0.0006246	0.0533999	0.9906675
Inverse variance weighted	23	-0.0215422	0.0456119	0.6367181
Simple mode	23	-0.0355365	0.0835044	0.6745600
Weighted mode	23	-0.0250483	0.0600569	0.6806644

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.75391	21	0.1472698
Inverse variance weighted	30.06811	22	0.1168184

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0085833	0.0064864	0.1999737

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009203	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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