Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 865)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0591873	0.1184239	0.6224181
Weighted median	23	0.0536423	0.0606998	0.3768414
Inverse variance weighted	23	0.0067344	0.0454715	0.8822629
Simple mode	23	0.0942882	0.1065460	0.3857523
Weighted mode	23	0.0841231	0.0953780	0.3873138

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.55836	21	0.1012286
Inverse variance weighted	29.88428	22	0.1213042

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0032212	0.006694	0.635347

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009064	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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