Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 864)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1381244	0.0998207	0.1809757
Weighted median	23	0.0507296	0.0542638	0.3498554
Inverse variance weighted	23	0.0336954	0.0390156	0.3877855
Simple mode	23	0.1015591	0.0844818	0.2420885
Weighted mode	23	0.0498009	0.0670286	0.4653543

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.69771	21	0.6680452
Inverse variance weighted	18.98952	22	0.6459754

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.006413	0.0056423	0.2685189

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000598	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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