Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 863)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0505189	0.0998207	0.6180607
Weighted median	23	0.0069872	0.0600792	0.9074153
Inverse variance weighted	23	0.0086302	0.0390155	0.8249366
Simple mode	23	-0.0447002	0.1092577	0.6864026
Weighted mode	23	-0.0030089	0.0734353	0.9676864

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.56892	21	0.7368830
Inverse variance weighted	16.98335	22	0.7642802

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0036324	0.0056424	0.5266974

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005161	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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