Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 862)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0308859	0.0998211	0.7600567
Weighted median	23	-0.0037153	0.0561037	0.9472006
Inverse variance weighted	23	-0.0103612	0.0390158	0.7905740
Simple mode	23	-0.0438037	0.0859081	0.6152056
Weighted mode	23	-0.0111943	0.0589428	0.8511151

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.56588	21	0.5488879
Inverse variance weighted	19.61578	22	0.6070596

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0012604	0.0056423	0.8253949

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005966	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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