Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 861)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1087985	0.1043886	0.3091489
Weighted median	23	-0.1170070	0.0562925	0.0376582
Inverse variance weighted	23	-0.0859573	0.0399166	0.0312854
Simple mode	23	-0.1853180	0.0945486	0.0627797
Weighted mode	23	-0.1136753	0.0643884	0.0913636

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.96611	21	0.3457879
Inverse variance weighted	23.02791	22	0.4001548

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0014027	0.0059006	0.8144022

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008448	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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