Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 860)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1388550	0.1085529	0.2147997
Weighted median	23	-0.0092339	0.0541035	0.8644829
Inverse variance weighted	23	-0.0169038	0.0428986	0.6935517
Simple mode	23	0.0075242	0.0876913	0.9323987
Weighted mode	23	-0.0022124	0.0640356	0.9727503

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.83524	21	0.2543706
Inverse variance weighted	26.59697	22	0.2269352

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.007489	0.0061359	0.2357963

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008116	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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