Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 859)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0014672	0.0998205	0.9884119
Weighted median	23	0.0787726	0.0526734	0.1347861
Inverse variance weighted	23	0.0605951	0.0390155	0.1203981
Simple mode	23	0.0653262	0.0888799	0.4701058
Weighted mode	23	0.0681666	0.0672448	0.3217422

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.50898	21	0.796574
Inverse variance weighted	15.96524	22	0.817607

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0038112	0.0056423	0.5067472

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005569	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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