Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 858)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0166741	0.1202133	0.8910051
Weighted median	23	0.0077872	0.0587550	0.8945600
Inverse variance weighted	23	0.0134017	0.0459866	0.7707253
Simple mode	23	0.0222881	0.0999934	0.8256730
Weighted mode	23	0.0065354	0.0734357	0.9298916

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.45694	21	0.0831831
Inverse variance weighted	30.56409	22	0.1053861

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.001847	0.006795	0.7884229

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009297	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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