Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 857)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2320034	0.1232549	0.0737256
Weighted median	23	0.0602481	0.0558067	0.2803273
Inverse variance weighted	23	0.0601967	0.0495709	0.2246120
Simple mode	23	0.0691265	0.0866337	0.4334475
Weighted mode	23	0.0560249	0.0707421	0.4368409

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.01835	21	0.0583003
Inverse variance weighted	35.51498	22	0.0342022

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0105506	0.0069669	0.1448361

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011482	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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