Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 856)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1189780	0.1115434	0.2982389
Weighted median	23	0.0290929	0.0528600	0.5820605
Inverse variance weighted	23	0.0085413	0.0437530	0.8452243
Simple mode	23	0.1062284	0.0795920	0.1956368
Weighted mode	23	0.0429390	0.0594279	0.4775739

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.22225	21	0.1981012
Inverse variance weighted	27.66699	22	0.1869816

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0067819	0.0063049	0.2942891

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008397	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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