Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 855)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1975744	0.0998167	0.0610332
Weighted median	23	0.0199405	0.0596059	0.7379729
Inverse variance weighted	23	-0.0275422	0.0397221	0.4880758
Simple mode	23	0.0676440	0.1013730	0.5115333
Weighted mode	23	0.0817117	0.1170466	0.4924205

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.37998	21	0.5607791
Inverse variance weighted	22.80495	22	0.4128126

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0104418	0.0056422	0.0783363

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007061	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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