Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 854)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1523482	0.0998202	0.1418750
Weighted median	23	-0.0274774	0.0554190	0.6200265
Inverse variance weighted	23	0.0038069	0.0400237	0.9242233
Simple mode	23	0.0046313	0.0939728	0.9611385
Weighted mode	23	-0.0445244	0.0609808	0.4730103

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.26323	21	0.5046472
Inverse variance weighted	23.15174	22	0.3932044

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0095894	0.0056423	0.1039799

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007018	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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