Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 853)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1653279	0.0998199	0.1125361
Weighted median	23	0.0093975	0.0572084	0.8695205
Inverse variance weighted	23	0.0234072	0.0397386	0.5558419
Simple mode	23	0.0907924	0.1107556	0.4211491
Weighted mode	23	0.0523413	0.0731765	0.4819613

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.43716	21	0.4937421
Inverse variance weighted	22.82308	22	0.4117765

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0087153	0.0056423	0.1373697

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007025	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8