Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 852)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0444565	0.1171139	0.7080538
Weighted median	23	0.0564825	0.0555049	0.3088612
Inverse variance weighted	23	0.0563000	0.0447350	0.2082026
Simple mode	23	0.0726939	0.0850230	0.4017711
Weighted mode	23	0.0518671	0.0570021	0.3727286

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.90640	21	0.1162668
Inverse variance weighted	28.92302	22	0.1470718

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0007273	0.0066198	0.9135571

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009395	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis