Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 851)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0022003	0.1023300	0.9830484
Weighted median	23	0.0336815	0.0548255	0.5389903
Inverse variance weighted	23	0.0297829	0.0391564	0.4468884
Simple mode	23	0.0904024	0.0924410	0.3387331
Weighted mode	23	0.0157185	0.0715034	0.8280317

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.06921	21	0.3955307
Inverse variance weighted	22.15934	22	0.4504132

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0016938	0.0057842	0.772518

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006891	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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