Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 850)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0350825	0.0998193	0.7287453
Weighted median	23	0.0316463	0.0610376	0.6041293
Inverse variance weighted	23	0.0327150	0.0390152	0.4017379
Simple mode	23	0.0313584	0.1066198	0.7714279
Weighted mode	23	0.0313584	0.0944711	0.7430792

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.80132	21	0.4711336
Inverse variance weighted	20.80199	22	0.5330030

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0001454	0.0056423	0.9796866

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006516	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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