Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 85)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1153498	0.0998201	0.2608336
Weighted median	23	0.0610289	0.0557178	0.2733760
Inverse variance weighted	23	0.0556621	0.0390155	0.1536765
Simple mode	23	0.0298465	0.0962779	0.7594759
Weighted mode	23	0.0627411	0.0620120	0.3226529

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.06521	21	0.6448738
Inverse variance weighted	18.48723	22	0.6767414

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0036654	0.0056423	0.5229744

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006219	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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