Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 849)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1138183	0.1334264	0.4032612
Weighted median	23	0.0536000	0.0576992	0.3529122
Inverse variance weighted	23	0.0465850	0.0513135	0.3639572
Simple mode	23	0.0339076	0.0945309	0.7232439
Weighted mode	23	0.0339076	0.0629723	0.5956715

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.51984	21	0.0146620
Inverse variance weighted	38.05529	22	0.0180618

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0041288	0.0075419	0.5898439

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011963	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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