Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 848)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2416600	0.1051368	0.0319004
Weighted median	23	-0.0401747	0.0639875	0.5301004
Inverse variance weighted	23	-0.0246883	0.0446967	0.5807083
Simple mode	23	-0.0372724	0.1381936	0.7898958
Weighted mode	23	-0.1469254	0.0800056	0.0798434

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.29789	21	0.3283035
Inverse variance weighted	28.87480	22	0.1484702

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0133244	0.0059429	0.0358831

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008871	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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