Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 847)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0790593	0.0998212	0.4372110
Weighted median	23	0.0152972	0.0559607	0.7845787
Inverse variance weighted	23	0.0267322	0.0390157	0.4932405
Simple mode	23	0.0145689	0.0865099	0.8678014
Weighted mode	23	-0.0161975	0.0669642	0.8111113

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.85129	21	0.5306975
Inverse variance weighted	21.17702	22	0.5098224

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0064966	0.0056424	0.2625082

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006559	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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