Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 846)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1206196	0.0998194	0.2403334
Weighted median	23	-0.0597622	0.0563897	0.2892318
Inverse variance weighted	23	-0.0348819	0.0390153	0.3712925
Simple mode	23	0.0573764	0.0993089	0.5692950
Weighted mode	23	-0.0579438	0.0680433	0.4036264

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.44991	21	0.7438636
Inverse variance weighted	17.32070	22	0.7454189

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0052652	0.0056423	0.3613428

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005491	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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