Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 845)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0886163	0.1166047	0.4557194
Weighted median	23	0.0119541	0.0640181	0.8518724
Inverse variance weighted	23	0.0214100	0.0456284	0.6389082
Simple mode	23	0.0808147	0.1226514	0.5167990
Weighted mode	23	0.0476748	0.0995503	0.6367343

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.65659	21	0.1224931
Inverse variance weighted	30.09064	22	0.1162779

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0067568	0.0065911	0.3169656

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009209	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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