Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 844)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0329133	0.0998204	0.7448737
Weighted median	23	0.0577590	0.0560412	0.3027039
Inverse variance weighted	23	0.0059612	0.0390156	0.8785630
Simple mode	23	0.0862840	0.0946216	0.3717136
Weighted mode	23	0.1071081	0.0761214	0.1733780

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.12390	21	0.6411505
Inverse variance weighted	18.20995	22	0.6934703

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0016551	0.0056424	0.7721409

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005525	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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