Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 843)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1132850	0.0998199	0.2692079
Weighted median	23	-0.0960401	0.0573884	0.0942268
Inverse variance weighted	23	-0.0234738	0.0390153	0.5474021
Simple mode	23	-0.0411044	0.1050643	0.6993902
Weighted mode	23	-0.0787887	0.0658740	0.2444091

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.02165	21	0.5198900
Inverse variance weighted	20.97714	22	0.5221512

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0055153	0.0056423	0.3394537

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006466	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8