Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 842)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1059262	0.0998201	0.3006643
Weighted median	23	0.0577818	0.0578540	0.3179152
Inverse variance weighted	23	0.0747870	0.0390153	0.0552555
Simple mode	23	0.1461285	0.0869626	0.1070330
Weighted mode	23	0.0561719	0.0667600	0.4091762

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.52048	21	0.5517894
Inverse variance weighted	19.63534	22	0.6058382

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019123	0.0056423	0.7380399

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007064	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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