Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 841)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0640241	0.0998201	0.5282056
Weighted median	23	-0.0015927	0.0537428	0.9763571
Inverse variance weighted	23	0.0093913	0.0390157	0.8097829
Simple mode	23	-0.0259006	0.0820847	0.7553289
Weighted mode	23	-0.0233220	0.0645163	0.7211812

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.54002	21	0.8453057
Inverse variance weighted	15.17848	22	0.8544652

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0045084	0.0056423	0.4332121

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004617	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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