Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 840)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0536592	0.1043872	0.6125912
Weighted median	23	0.0161329	0.0570377	0.7772940
Inverse variance weighted	23	0.0018533	0.0401372	0.9631723
Simple mode	23	-0.0087616	0.0905825	0.9238207
Weighted mode	23	0.0165517	0.0625930	0.7939077

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.96519	21	0.3458372
Inverse variance weighted	23.28311	22	0.3858939

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0031814	0.0059005	0.5954359

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007056	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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