Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 84)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1388974	0.0998190	0.1786419
Weighted median	23	-0.0830183	0.0564114	0.1411133
Inverse variance weighted	23	-0.0732712	0.0390151	0.0603786
Simple mode	23	-0.0654535	0.0881537	0.4656434
Weighted mode	23	-0.0825804	0.0630968	0.2041133

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.14499	21	0.5758399
Inverse variance weighted	19.65517	22	0.6045998

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0040301	0.0056423	0.4829231

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007025	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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