Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 839)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0322846	0.1176083	0.7863755
Weighted median	23	0.0655017	0.0580995	0.2595715
Inverse variance weighted	23	0.0359975	0.0449124	0.4228393
Simple mode	23	0.0599612	0.0922824	0.5225760
Weighted mode	23	0.0636173	0.0636109	0.3281358

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.15129	21	0.1104165
Inverse variance weighted	29.15292	22	0.1405464

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.000228	0.0066478	0.9729626

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009092	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8