Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 838)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0061150	0.1185111	0.9593362
Weighted median	23	-0.0034240	0.0572064	0.9522730
Inverse variance weighted	23	0.0259604	0.0453492	0.5670133
Simple mode	23	0.0229336	0.0945438	0.8105846
Weighted mode	23	0.0080083	0.0597922	0.8946710

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.60058	21	0.1003131
Inverse variance weighted	29.72245	22	0.1253678

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0019697	0.0066988	0.7716109

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009141	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8