Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 837)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1031763	0.0998202	0.3130708
Weighted median	23	0.0063185	0.0552114	0.9088868
Inverse variance weighted	23	0.0036479	0.0390156	0.9255084
Simple mode	23	0.0529252	0.1045290	0.6176679
Weighted mode	23	0.0166261	0.0692788	0.8125618

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.73378	21	0.7844176
Inverse variance weighted	17.08554	22	0.7586229

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0065601	0.0056423	0.2580129

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000518	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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