Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 836)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0088314	0.0998213	0.9303399
Weighted median	23	0.0309278	0.0546770	0.5716347
Inverse variance weighted	23	-0.0027968	0.0390158	0.9428535
Simple mode	23	0.0442545	0.0893367	0.6252523
Weighted mode	23	0.0229804	0.0657489	0.7300244

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	10.13407	21	0.9771181
Inverse variance weighted	10.13839	22	0.9850060

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0003706	0.0056424	0.9482551

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003074	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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